Scientific basis
Will follow
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Pain is primarily about cell/organism survival not tissue integrity
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Nociception does not come from tissue structures, but primarily from the fluid surrounding those structures
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If no tissue damage is demonstrated in a patient, this does not mean that nothing is wrong. The primary source of nocisensory activity is environmental disturbance and this is not demonstrated by imaging studies.
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Virtually all chronic pain is nociceptive
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(Pain without tissue damage is the norm rather than the exception)
Most of the nociception is interoceptive.
A-delta nociceptors - exteroception - skin/tissue damage -> S1 sensory cortex: sharp, localized pain
C-fiber nociceptors - interoception - fascia /homeostasis _cc7 81905-5cde-3194-bb3b-136bad5cf58d_ -> insula and hypothalamus: diffuse deep aching pain, _cc781905-5cde-3 194-bb3b-136bad5cf58d_ _cc781905 -5cde-3194-bb3b-136bad5cf58d_ _cc781905-5cde-3194-bb3b-136bad5c f58d_ _cc781905-5cde-3194- bb3b-136bad5cf58d_ _cc7 81905-5cde-3194-bb3b-136bad5cf58d_ _cc781905- 5cde-3194-bb3b-136bad5cf58d_ _cc781905-5cde-3194-bb3b-136bad5c f58d_ _cc781905-5cde-3194-bb3b -136bad5cf58d_ _cc78190 5-5cde-3194-bb3b-136bad5cf58d_ _cc781905-5cde -3194-bb3b-136bad5cf58d_ _cc781905-5cde-3194-bb3b-136bad5cf58d _ _cc781905-5cde-3194-bb3b- 136bad5cf58d_ _cc78190 5-5cde-3194-bb3b-136bad5cf58d_ _cc781905-5cde- 3194-bb3b-136bad5cf58d_ _cc781905-5cde-3194-bb3b-136bad5cf58d _ _cc781905-5cde-3194-bb 3b-136bad5cf58d_ _cc781905-5cde-3194 -bb3b-136bad5cf58d_ often a sore feeling, often stated in emotional terms
There have been 25 studies that measured the chemical environment of the fluid in various pain syndromes and all found this acidification.
Configurations of Hyaluron: